Correction: Multi-site spinal stimulation strategies to enhance locomotion after paralysis.

Multi-site spinal stimulation strategies to enhance locomotion after paralysis

Initiation of Bladder Voiding with Epidural Stimulation in Paralyzed, Step Trained Rats

The inability to control timely bladder emptying is one of the most serious challenges among the several functional deficits that occur after a complete spinal cord injury. Having demonstrated that electrodes placed epidurally on the dorsum of the spinal cord can be used in animals and humans to recover postural and locomotor function after complete paralysis, we hypothesized that a similar app...

Inducing hindlimb locomotor recovery in adult rat after complete thoracic spinal cord section using repeated treadmill training with perineal stimulation only.

Although a complete thoracic spinal cord section in various mammals induces paralysis of voluntary movements, the spinal lumbosacral circuitry below the lesion retains its ability to generate hindlimb locomotion. This important capacity may contribute to the overall locomotor recovery after partial spinal cord injury (SCI). In rats, it is usually triggered by pharmacological and/or electrical s...

Towards a Spinal Neuroprosthesis: Restoring Locomotion after Spinal Cord Injury

The overall goal of this work is to develop the core framework for an implantable neuroprosthetic device that can restore locomotion after a severe spinal cord injury (SCI) causes paralysis. Our approach to this problem relies on a combination of the biological central pattern generator (CPG) for locomotion and an artificial silicon CPG. In particular, we propose that an artificial CPG can be u...

The role of the serotonergic system in locomotor recovery after spinal cord injury

Serotonin (5-HT), a monoamine neurotransmitter synthesized in various populations of brainstem neurons, plays an important role in modulating the activity of spinal networks involved in vertebrate locomotion. Following spinal cord injury (SCI) there is a disruption of descending serotonergic projections to spinal motor areas, which results in a subsequent depletion in 5-HT, the dysregulation of...